灵活的手套式电化学生物传感器

一种灵活的手套式电化学生物传感器

具有高度可拉伸的印刷电极系统

开发为可穿戴的防御点使用筛选工具

和食品安全应用。这是一次性机械的

坚固的“手套实验室”集成了可伸缩的可印刷品

基于酶的生物传感系统和用于滑动的活性表面

在不同的手指上采样，并与紧凑相结合

用于电化学检测和实时的电子接口

无线数据传输到智能手机设备。 Stressenduring

墨水用于打印电极系统和

长蛇形连接到无线电子接口。

动态机械变形，弯曲和拉伸研究

说明印刷痕迹的弹性和顺应性

防止这种胶片的极端机械变形

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采样/传感操作。食指上的有机磷水解酶（OPH）生物传感器系统能够实现

在可疑表面和农产品上快速现场检测有机磷（OP）神经毒剂化合物

跟随他们在拇指上的滑动收集。新的基于无线手套的生物传感器系统具有相当大的前景

用于国防和食品安全应用中OP神经毒剂和农药的现场筛查，具有显着的速度和成本

好处。这种“手套实验室”演示打开了灵活的可穿戴传感器领域，面向未来的现场多路复用

各种领域的化学检测。

关键词：可穿戴传感器，手套实验室，拉伸，化学战剂，有机磷水解酶，机械应力，

ABSTRACT: A flexible glove-based electrochemical biosensor

with highly stretchable printed electrode system has been

developed as a wearable point-of-use screening tool for defense

and food security applications. This disposable-mechanically

robust “lab-on-a-glove” integrates a stretchable printable

enzyme-based biosensing system and active surface for swipe

sampling on different fingers, and is coupled with a compact

electronic interface for electrochemical detection and real-time

wireless data transmission to a smartphone device. Stressenduring

inks are used to print the electrode system and the

long serpentine connections to the wireless electronic interface.

Dynamic mechanical deformation, bending, and stretching studies

illustrate the resilience and compliance of the printed traces

against extreme mechanical deformations expected for such onglove

sampling/sensing operation. An organophosphorus hydrolase (OPH)-based biosensor system on the index finger enables

rapid on-site detection of organophosphate (OP) nerve-agent compounds on suspicious surfaces and agricultural products

following their swipe collection on the thumb finger. The new wireless glove-based biosensor system offers considerable promise

for field screening of OP nerve-agents and pesticides in defense and food-safety applications, with significant speed and cost

advantages. Such “lab-on-a-glove” demonstration opens the area of flexible wearable sensors to future on-the-hand multiplexed

chemical detection in diverse fields.

KEYWORDS: wearable sensor, lab-on-a-glove, stretching, chemical warfare agent, organophosphorus hydrolase, mechanical stress,

food security